Emilio Bonifacio, Edwin Encarnacion and Brett Lawrie also homered for the Blue Jays, who have won just seven of their last 20 and are last in the AL East at 15-24.
Chad Jenkins (1-0) got his second major league win and first since Oct. 2, allowing two runs and seven hits in five innings-plus. It was just the fourth big league start and 14th appearance for Jenkins, who missed most of spring training and the start of the season with shoulder inflammation.
Mike Napoli and Pedro Ciriaco homered for Boston, which has lost eight of 10 following a 20-8 start under new manager John Farrell.
Ryan Dempster (2-4) gave up six runs and seven hits in five innings, his shortest start this season. The British Columbia native had been 6-0 against Toronto and Montreal in his big league career.
Boston’s Shane Victorino crashed into right-field wall in the fourth while catching Colby Rasmus’ drive and fell to the ground, writhing in pain. After being attended to by team personnel, Victorino remained in the game but left after the sixth inning.
Munenori Kawasaki hit a two-run single in the second and Bautista sent Dempster’s first pitch of the third into the seats above the Green Monster in left.
Bonifacio hit a two-run homer in the fourth for a 5-0 lead, his first home run since last July 23 for Miami.
Napoli led off the fourth with his seventh homer, and Encarnacion homered in the fifth to make it 6-1. Lawrie homered off Andrew Miller leading off the sixth and Bautista hit a tworun drive off Clayton Mortensen later in the inning for a 10-1 lead, Bautista’s ninth homer this year. He has 18 career multihomer games.
Ciriaco opened the eighth with his first home run since Aug. 26.
Notes — Red Sox designated hitter David Ortiz had a scheduled day off after playing in 19 games since returning from an injury April 20. He is in a 1-for- 17 slump after hitting .414 with four homers and 17 RBIs through his first 15 games. … Bautista has reached safely in 18 of his last 19 games. … Farrell said closer Andrew Bailey, on the DL with a right biceps strain, likely will throw off a mound Tuesday and the team then will decide whether he will require a rehab stint. … Boston catcher David Ross was placed on the seven-day concussion DL. The team recalled catcher Ryan Lavarnway from Triple-A Pawtucket. … Ciriaco entered the game as a defensive replacement in the seventh, making his first big league appearance at first base.
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