The Associated Press

NEW YORK

Roger Federer served poorly. He volleyed poorly. Closed out sets poorly, too. And now he’s gone, beaten at the U. S. Open by an opponent ranked outside the top 50 for the first time in his illustrious career.

Looking slow and tired on a sweltering night in Arthur Ashe Stadium, the No. 2-seeded Federer double-faulted 10 times, failed to convert a trio of set points and lost 3-6, 7-5, 7- 6 ( 7), 7- 6 ( 3) in the fourth round to John Millman in a match that began Monday and concluded at nearly 1 a.m. on Tuesday.

I t ’ s only the second time in Federer’s past 14 appearances at the U.S. Open that he’s lost before the quarterfinals. He is, after all, a five- time champion at the tournament, part of his men’s- record haul of 20 Grand Slam titles.

So much for that highly anticipated matchup between Federer and 13-time major champion Novak Djokovic in the quarterfinals. Instead, it’ll be the 55th- ranked Millman, who had never made it past the third round at a Slam until last week, taking on No. 6 seed Djokovic.

Hours before, Djokovic left the court for a medical timeout — the second time during the tournament he’s sought help from a doctor because of harsh weather — during what would become an otherwise straightforward 6- 3, 6- 4, 6- 3 victory over 68th-ranked Joao Sousa of Portugal.

The other quarterfinal on the bottom half of the draw will be a rematch of the 2014 U.S. Open final: No. 7 Marin Cilic against No. 21 Kei Nishikori.