SANTA CLARA, Calif.

Tom Brady threw for 280 yards and four touchdowns and the New England Patriots beat San Francisco 30-17 on Sunday in Brady’s first road game against the 49ers team he rooted for as a boy.

Brady found Danny Amendola for a 5-yard touchdown to start the fourth quarter then later hit Malcolm Mitchell on a 56-yard score for his fourth TD pass.

Brady also threw short touchdown passes to Julian Edelman and James White on his first two possessions and completed 24 of 40 passes. The AFC East-leading Patriots (8-2) bounced back from last week’s loss to the Seahawks on a rainy day at Levi’s Stadium.

With his 199th career victory, Brady tied Hall of Famer Brett Favre for second most wins by a quarterback in NFL history. With his next win, Brady will match Peyton Manning for the top spot.

Redskins 42, Packers 24

LANDOVER, Md. (AP) — Kirk Cousins went deep late and often, throwing for 375 yards and three touchdowns to lead Washington past free-falling Green Bay.

Cousins and the Redskins (6-3-1) have won six of their past eight games going into a showdown with the NFC East-leading Dallas Cowboys, the winners of nine in a row. The Packers (4-6) have lost four consecutive games and five of six, allowing 30 or more points in all of those defeats.

Seahawks 26, Eagles 15

SEATTLE (AP) — Russell Wilson threw for 272 yards and a touchdown, and caught a 15-yard touchdown pass from Doug Baldwin and Seattle rolled past Philadelphia.

Steelers 24, Browns 9

CLEVELAND ( AP) — Le’Veon Bell scored on a 1- yard touchdown run long after time expired in the first half and Pittsburgh had eight sacks and snapped a four-game losing streak with a win over winless Cleveland.

Cowboys 27, Ravens 17

ARLINGTON, Texas (AP) — Dak Prescott threw three touchdown passes, two to Dez Bryant, in the first game with Tony Romo as his backup, and the Cowboys set a franchise season record with their ninth straight win.

Vikings 30, Cardinals 24

MINNEAPOLIS (AP) — Xavier Rhodes returned one of his two interceptions 100 yards for a touchdown and Cordarrelle Patterson took the second-half kickoff 104 yards for a score as the Vikings stopped their four-game losing streak.

Dolphins 14, Rams 10

LOS ANGELES (AP) — DeVante Parker caught a 9- yard touchdown pass from Ryan Tannehill with 36 seconds to play, and Miami rallied for two late scores to spoil Jared Goff ’s NFL debut with a victory over Los Angeles.

Bucs 19, Chiefs 17

KANSAS CITY, Mo. (AP) — Jameis Winston sliced up a Kansas City defense missing top cornerback Marcus Peters, and Tampa Bay snapped the Chiefs’ five-game winning streak.

Bills 16, Bengals 12

CINCINNATI (AP) — LeSean McCoy ran 7 yards for a touchdown before suffering a thumb injury, for the Bills (5-5), who had lost three straight heading into their bye week.

Giants 22, Bears 16

EAST RUTHERFORD, N.J. (AP) — Eli Manning threw a go-ahead 15-yard touchdown pass to rookie Sterling Shepard in the third quarter as the Giants rallied for their fifth straight win.

Colts 24, Titans 17

INDIANAPOLIS (AP) — Andrew Luck led the Indianapolis Colts to a big early lead, and the defense held on in the second half. Indianapolis (5-5) evened its record by winning back-to-back games for the first time this season.

Lions 26, Jaguars 19

DETROIT (AP) — Eric Ebron had a go-ahead 1-yard touchdown run early in the fourth quarter. Ebron’s first carry of his career, a hand-off as he went from left to right after lining up as an off-the-line tight end, was set up by his career-long, 61- yard catch.