OAKLAND, Calif.

Latavius Murray ran for 114 yards and three touchdowns and the Oakland Raiders showed they were ready for prime time, beating the defending Super Bowl champion Denver Broncos 30-20 on Sunday night.

In what was being billed as the biggest game in Oakland since the team went to the Super Bowl following the 2002 season, the Raiders (7-2) put together a complete effort to overpower the Broncos (6-3) and take over sole possession of first place in the AFC West.

Derek Carr threw for 184 yards and did not turn the ball over, Khalil Mack had two sacks, a forced fumble and a fumble recovery and the Raiders out-rushed Denver 218-33.

Panthers 13, Rams 10

LOS ANGELES (AP) — Cam Newton persevered through five sacks to pass for 225 yards and a touchdown, and Carolina’s defense shut down Los Angeles.

Greg Olsen caught a touchdown pass in the first half and Graham Gano added two fourth-quarter field goals for the Panthers (3-5), who won their second straight after a four-game skid.

Lions 22, Vikings 16

MINNEAPOLIS (AP) — Matthew Stafford threw a 28- yard touchdown pass to Golden Tate, who vaulted into the end zone in overtime to lift Detroit past Minnesota.

After Matt Prater kicked a 58-yard field goal as time expired to force overtime, Tate finished the opening drive when he ran through arm tackles by Xavier Rhodes and Harrison Smith and leaped in for the winning score.

Cowboys 35, Browns 10

CLEVELAND (AP) — Rookie quarterback Dak Prescott threw three touchdown passes and kept any talk for Tony Romo unnecessary, leading Dallas over winless Cleveland.

Rookie Ezekiel Elliott rushed for 92 yards and scored twice and durable tight end Jason Witten had 134 yards receiving for the Cowboys, off to their best start since 2007.

Giants 28, Eagles 23

EAST RUTHERFORD, N.J. (AP) — Eli Manning threw for four touchdowns and New York’s defense had two interceptions and three stops on fourth downs to beat Philadelphia.

The Giants (5-3) won their third straight game, holding off the Eagles (4-4 after a 3-0 start) after Manning was intercepted with less than two minutes to go.

Ravens 21, Steelers 14

BALTIMORE (AP) — Joe Flacco threw a 95-yard touchdown pass to Mike Wallace, and Baltimore frustrated an ineffective Ben Roethlisberger in a victory over Pittsburgh.

Baltimore (4-4) snapped a four-game losing streak and moved into a tie atop the AFC North with the Steelers (4-4), who have dropped three in a row.

Saints 41, 49ers 23

SANTA CLARA, Calif. (AP) — Drew Brees threw a pair of touchdown passes to Michael Thomas and another to Mark Ingram, who also ran for a 75-yard score a week after being benched and New Orleans beat lowly San Francisco.

Ingram, replaced by Tim Hightower during last Sunday’s 25-20 win against Seattle after fumbling for a second straight game, scored his second straight TD for the Saints on a career-long run to answer immediately after DuJuan Harris caught a 47-yard touchdown pass from Colin Kaepernick. Ingram’s run also was the second-longest in Saints history and he wound up with 158 yards rushing as San Francisco allowed an opposing 100-yard runner for the seventh straight game.

Chargers 43, Titans 35

SAN DIEGO (AP) — Melvin Gordon ran for a career-high 196 yards and scored the go-ahead TD on a 1-yard run, and defensive backs Dwight Lowery and Brandon Flowers scored on turnovers by Marcus Mariota to lead the Chargers over Tennessee, which still hasn’t won in San Diego since 1990.

Colts 31, Packers 26

GREEN BAY, Wis. (AP) — Frank Gore rushed for two touchdowns, Jordan Todman had a tone-setting 99- yard return on the opening kickoff and Indianapolis held on for a win over Green Bay.

Dolphins 27, Jets 23

MIAMI GARDENS, Fla. (AP) — Rookie Kenyan Drake scored untouched on a 96-yard kickoff return with 5:15 left, and Miami won a seesaw battle with New York Jets.

Jay Ajayi rushed for 111 yards and helped to run out the clock after the Dolphins came from behind for the third time.

Chiefs 19, Jaguars 14

KANSAS CITY, Mo. (AP) — Kansas City stuffed Jacksonville on fourth down with less than 2 minutes left deep in its own territory, preserving a victory despite finishing without five offensive starters.

Nick Foles threw for 187 yards and a first-half touchdown toss to Albert Wilson, and helped to set up four field goals by Cairo Santos, as Kansas City (6-2) won its 10th consecutive home game.