NEW YORK — The flesh-colored, skin-tight beaded gown Marilyn Monroe wore during her breathless rendition of “Happy Birthday” to President John F. Kennedy is going on the auction block this fall.

Julien’s Auctions is offering the sequined stunner at a sale in Los Angeles on Nov. 17.

The auction house believes the gown could fetch $2 million to $3 million.

The sultry actress wore the barely-there dress at Kennedy’s 45th birthday celebration at Madison Square Garden on May 19, 1962. Made of silk gauze and covered in thousands of rhinestone beads and sequins, the Jean Louis dress was so formfitting that Monroe had to be sewn into it.

She died less than three months later of an overdose of sleeping pills at age 36. Kennedy died the following year.

The custom-made, one-of-a-kind dress is “not only Hollywood, but political and historical,” said Julien’s president Darren Julien.

The dress was first purchased 17 years ago at Christie’s auction by the late financier Martin Zweig, who kept it in a climate-controlled display case at his Pierre Hotel penthouse in New York. It is being sold by his estate.

“She called it skin and beads,” said Julien of the gown. And because the dress “was sewn on Marilyn Monroe, Zweig had it professionally mounted on a mannequin. It’s never been off it, and is immaculately preserved.”

The dress was last sold at auction in 1999 for $1.26 million, the highest auction price for a Monroe dress to date.

The dress is among some 1,300 Monroe artifacts being offered by Julien’s over three days. They include items from the estate of Monroe’s acting coach Lee Strasberg and from David Gainsborough-Roberts, a British collector believed to have the largest private collection of Monroe costumes.

A sheer black beaded and sequined dress from the movie “Some Like it Hot” also is for sale.