NASHVILLE, Tenn. (AP) — Brian Hoyer threw a 6-yard touchdown pass to Travis Benjamin with 1:09 left, and the Browns rallied from a 25-point deficit in beating the Tennessee Titans 29-28 Sunday for the biggest comeback in franchise history.

The Browns (2-2) had never rallied from more than 20 points, and easily topped the comeback on Dec. 4, 1966, when Cleveland trailed the Giants 34-14 and won 49-40, according to STATS. It was the biggest road comeback in NFL history.

They couldn’t have made it tougher on themselves as they fell behind 28-3 in the first half. They snapped a seven-game road skid scoring 26 unanswered points, including 16 in the fourth quarter.

Jake Locker didn’t return after hurting his right thumb in the second quarter, and backup Charlie Whitehurst couldn’t protect the big lead.

Saints 37, Buccaneers 31, OT

NEW ORLEANS (AP) — Khiry Robinson’s tackle-breaking, 18-yard touchdown run in overtime lifted the Saints.

Pierre Thomas caught eight passes out of the backfield for 77 yards and a touchdown. He also rushed for 35 yards and a score to help New Orleans (2-3) overcome Drew Brees’ three interceptions ”“ and an 11-point deficit in the fourth quarter.

Brees completed 35 of 57 passes for 371 yards and two touchdowns, but two of his interceptions led directly to Buccaneers touchdowns. His third ended a potential winning drive in the final minute of regulation.

Making his second straight start for Tampa Bay (1-4), Mike Glennon was 19 for 32 for 249 yards and two touchdowns. He was intercepted once and sacked by Junior Galette for a safety in the fourth quarter.

Cowboys 20, Texans 17, OT

ARLINGTON, Texas (AP) — Dan Bailey kicked a 49-yard field goal in overtime after a miss at the end of regulation ended his franchise record streak of made kicks. Bailey’s kick was set up when Tony Romo threw off his back foot with pressure coming and Dez Bryant made a spectacular leaping catch for 37 yards.

The Cowboys (4-1) won their fourth straight for the first time since 2011 despite blowing a 10-point lead in the fourth quarter.

The Texans (3-2) rallied behind Arian Foster, who had 157 yards rushing and a tying 1-yard score with 41 seconds left in regulation.

Bailey’s miss from 53 yards on the final play of regulation ended a franchise record streak of 30 straight made field goals.

Broncos 41, Cardinals 20

DENVER (AP) — Peyton Manning joined Brett Favre in the NFL’s most exclusive of clubs with his 500th touchdown pass.

Manning finished with four TD throws, moving him within five of Favre’s record 508. Manning found tight end Julius Thomas twice in the end zone, including the touchstone touchdown, a 7-yard dart in the first quarter.

Yet, it was wide receiver Demaryius Thomas who had the biggest day for the Broncos (3-1) with eight catches for a team-record 226 yards and two TDs. That beat Shannon Sharpe’s mark of 214 yards set against Kansas City in 2002.

Arizona (3-1) saw quarterback Drew Stanton leave with a possible concussion.

Chargers 31, Jets 0

SAN DIEGO (AP) — Philip Rivers threw two touchdown passes to Antonio Gates and rookie running back Branden Oliver’s big day included his first two NFL touchdowns.

The Chargers (4-1) heaped more pain on the Jets (1-4), who lost their fourth straight game and turned to Michael Vick. Vick replaced Geno Smith on New York’s first possession of the second half, but wasn’t any more effective.

Other than being sacked three times, Rivers had his way with the Jets. He was 20 of 28 for 288 yards and three touchdowns, with one interception.

It was the first shutout in the NFL this season.

The Chargers’ last shutout victory was 31-0 against Kansas City on Dec. 12, 2010. The Jets were blanked for the first time since losing 34-0 against San Francisco on Sept. 30, 2012.

Bills 17, Lions 14

DETROIT (AP) — Dan Carpenter hit a 58-yard field goal with 4 seconds remaining to lift Buffalo.

Kyle Orton, making his debut as Bills starter, set up the decisive kick by completing a 20-yard pass over the middle to Sammy Watkins as Buffalo (3-2) overcame a 14-0 deficit. It was the eighth game Orton has won in overtime or when trailing in the fourth quarter.

The Lions (3-2) were undone by kicker Alex Henery missing all three field-goal attempts, including a 50-yarder wide left with 21 seconds left.

Giants 30, Falcons 20

EAST RUTHERFORD, N.J. (AP) — First-round draft pick Odell Beckham Jr. made his NFL debut a memorable one, catching a go-ahead 15-yard touchdown pass from Eli Manning with 10:02 left.

Fellow rookie Andre Williams scored on a 3-yard run to ignite the second-half rally that saw the Giants (3-2) come from 10 points down to win their third straight game.