WIMBLEDON, England (AP) — Racket bag slung over her shoulder, resignation written across her face, Venus Williams weaved through fans milling about on the sidewalks that players must traverse to get from Court 2 to the Wimbledon locker rooms.

The 32-year-old Williams had just absorbed a lopsided first-round loss at the Grand Slam tournament she once ruled, a poor performance that raised questions about how much longer she will keep playing tennis while dealing with an energy-sapping illness.

She trudged by as her hitting partner, David Witt, was saying: “It’s tough to watch sometimes. I think everybody sees it. I don’t know what else to say.”

Looking lethargic, and rarely showing off the power-based game that carried her to five Wimbledon titles and seven majors overall, Williams departed meekly Monday with a 6-1, 6-3 defeat against 79th-ranked Elena Vesnina of Russia. Only once before — as a teenager making her Wimbledon debut in 1997 — had Williams exited so early at the All England Club.

She hadn’t lost in the first round at any Grand Slam tournament in 6 1/2 years. Still, Williams said she’ll be at the London Olympics next month and is “planning” to be back at Wimbledon next year.

Her loss, in her first match since a second round ouster at the French Open, was part of an odd Day 1, even if the true tournament favorites in action won easily: Novak Djokovic, Roger Federer, Maria Sharapova. Among those sent home were sixth-seeded Tomas Berdych, the 2010 runner-up at Wimbledon; 11thseeded John Isner; No. 16 Flavia Pennetta; and No. 18 Jelena Jankovic, who was rather easily beaten 6-2, 6-4 by Kim Clijsters, a four-time major champion who has been beset by injuries in her last season on tour and, like Williams, is unseeded.

Other seeded losers: No. 23 Andreas Seppi, No. 24 Marcel Granollers and No. 27 Daniela Hantuchova of Slovakia, who was upset by 100th-ranked Jamie Hampton of the United States 6-4, 7-6 (1).

Truth be told, the biggest surprise might very well have been the way Isner — the highest-ranked American man — blew a match point, wasted a two-sets-toone lead, dropped a tiebreaker on grass, and bid a 6-4, 6-7 (7), 3-6, 7-6 (7), 7-5 farewell to Wimbledon in the first round against 73rd-ranked Alejandro Falla.