ST. LOUIS — John Lackey struck out 11 in seven innings of four-hit ball against his former team and had an RBI single Monday night, leading the Chicago Cubs over the St. Louis Cardinals, 5-0.

Jayson Heyward, playing at Busch Stadium for the first time since leaving to sign with Chicago, was 0 for 4, made two nice catches in right field and was booed throughout.

Dexter Fowler homered for the second time in three days for the Cubs, a major league-best 10-3 and off to their best start since 1970. Chicago has won 15 of its last 16 regular-season road games, going 6-1 this year.

Fowler homered in the sixth, and shortstop Aledmys Diaz misplayed a potential double-play grounder in the Cubs’ three-run seventh, throwing the ball wildly for an error as a run scored. Addison Russell had a sacrifice fly and Lackey, who entered with a .111 career batting average, singled for a 4-0 lead and his seventh RBI in 129 career at-bats.

Mike Leake (0-2) allowed four runs, three earned, and six hits in seven innings in his St. Louis debut. At the plate, he botched a squeeze bunt in the fifth, although Kolten Wong scrambled back to third safely to Lackey’s ire.

ROCKIES 5, REDS 1: Trevor Story’s solo homer snapped a tie in the eighth inning, and Jordan Lyles got his first victory in nearly a year, leading Colorado at Cincinnati.

Story added to his incredible rookie start, connecting on the first pitch from Ross Ohlendorf (2-2) for his NL-leading eighth homer in only 13 games. Ben Paulsen completed the rally with a three-run homer off Jumbo Diaz.

Lyles (1-1) allowed four hits and one unearned run in seven innings for his first win since April 23 last year. He missed most of last season with injuries and had been 0-5 in his last eight starts with an 8.35 ERA. He hadn’t lasted five innings yet this season.

MARLINS 6, NATIONALS 1: Jose Fernandez overcame early wildness, pitching six innings to help Miami win at home.

Fernandez (1-1) threw 54 pitches in the first two innings but didn’t allow a hit until the fifth. His victory was the first this season for a Marlins starter. Miami won at home for the first time this year in six tries.

METS 5, PHILLIES 2: David Wright homered twice for his first two RBI this season and New York went deep four times at Philadelphia.

Lucas Duda and Neil Walker hit consecutive homers in the eighth inning for New York, which has 11 homers in its last four games after hitting two in its first eight. The power surge has helped the Mets win 4 of 5 following a four-game skid that produced a 2-5 start.

AMERICAN LEAGUE

ANGELS 7, WHITE SOX 0: Hector Santiago matched a career high with 10 strikeouts over seven crisp innings, and Los Angeles won at Chicago.

Kole Calhoun, Andrelton Simmons and Geovany Soto hit consecutive RBI singles during a five-run first, matching the Angels’ season high for runs in an entire game. Mike Trout scored on a throwing error by first baseman Jose Abreu, and Johnny Giavotella capped the opening outburst with another RBI single.