Garrett Whitlock agreed to a four-year contract to remain in Boston at least through 2026. Steve Helber/Associated Press

NEW YORK — The Boston Red Sox signed right-handed reliever Garrett Whitlock to an $18.75 million, four-year deal Sunday covering 2023-26 that includes two club options and escalators that could increase the total to $44.5 million over six seasons.

The agreement was announced by Chief Baseball Officer Chaim Bloom before Boston played the finale of a three-game series against the rival New York Yankees.

The Red Sox poached Whitlock from the Yankees in the winter meeting draft ahead of the 2021 season. A starter in the minors, the 25-year-old Whitlock moved to the bullpen and led all Boston pitchers with a 1.96 ERA over 73 1/3 innings. He was 8-4 with 81 strikeouts and 17 walks while frequently pitching multiple innings per appearance.

“We hope we’re just scratching the surface of what he can accomplish,” Bloom said. “The fact that, he’s said a few times, you give him the ball and he’ll get outs until you take it from him, that’s perfect.”

Whitlock was an 18th-round draft pick by New York in 2017 and had Tommy John surgery in 2019. When the 2020 minor league season was canceled due to the pandemic, he coached a travel-ball team and worked landscaping to make ends meet back home in Alabama.

The Yankees left him unprotected the next offseason for the winter meeting draft, and Boston took a chance on him.

Among 30 rookies who pitched at least 70 innings in 2021, Whitlock ranked first in ERA, second in WHIP at 1.10, and third in opponent OPS at .631.

“Last year when they took me in the Rule 5 draft, it was an honor then, just because the fact they took a chance on me, everything like that,” Whitlock said. “I just want to work my tail off.”

Bloom said the sides agreed to the deal hours before Boston’s season-opener Friday. Whitlock made his season debut that day, allowing a run over 2 1/3 innings in relief against New York, striking out four and allowing a homer to DJ LeMahieu in a 6-5 defeat.

Whitlock had agreed last month to a one-year contract paying $720,000 while in the major leagues and $285,250 while in the minors.

The new deal includes a $1 million signing bonus, $1 million in 2023, $3.25 million in 2024, $5.25 million in 2025 and $7.25 million in 2026. Boston has an $8.25 million club option for 2027 with a $1 million buyout and a $10.5 million option for 2028 with a $500,000 buyout.

The options have up to $4 million each in esclators for innings and awards, such as Cy Young Award and Mariano Rivera/Trevor Hoffman reliever of the year. Whitlock remains eligible for the new $50 million bonus pool for pre-arbitration-eligible players.

• Boston Red Sox newcomer Trevor Story is out of the lineup for Sunday night’s game against the New York Yankees and away from the team with flu-like symptoms.

The two-time All-Star had a hit in Boston’s 4-2 loss to the Yankees on Saturday, but the second baseman felt ill enough Sunday to take a COVID-19 test, which came back negative.

Red Sox Manager Alex Cora said Story “doesn’t feel great,” but he was hopeful it was a 24-hour flu and that Story could rejoin the team by Monday.

Cora said a bug had been going around Boston’s minor league camp toward the end of spring training. No one else on the major league roster had similar symptoms.

CARDINALS: Manager Oliver Marmol missed his second successive game on Sunday against Pittsburgh after being diagnosed with the flu.

The 35-year-old was sent home prior to Saturday’s game and team doctors felt he should remain there until his condition improved.

Bench coach Skip Schumaker will handle the managerial duties again.

“He’s a little better today,” Schumaker said. “Just got off the phone with him. Hopefully tomorrow is a new day and he’ll be back.”

Schumaker indicated that he and Marmol went over strategies and pitching rotations decisions during their conversation.

Schumaker played 11 years in the majors, eight with St. Louis. He hit 23 homers and drove in 211 runs as a member of the Cardinals. He was hired as bench coach on Nov. 6, 2021.

Marmol, the youngest manager in the majors, won his debut 9-0 on Thursday.

PADRES: San Diego scratched starting pitcher Blake Snell from the lineup just before game time.

The 2018 AL Cy Young winner went through his usual warm up before the game but right-hander Nabil Crismatt came out to the mound for the first inning against the Arizona Diamondbacks.

The Padres said Snell didn’t start because of “left adductor tightness.”

It’s the first bad news for a Padres rotation that’s been brilliant through the first three games. Yu Darvish and Sean Manaea threw 13 innings of no-hit baseball on back-to-back days and Joe Musgrove was solid on Saturday, giving up two runs over six innings.