Patriots tight end Ryan Izzo fumbles after being hit by Broncos cornerback Michael Ojemudia – one of three New England turnovers in an 18-12 loss at Foxborough, Mass. Charles Krupa/Associated Press

FOXBOROUGH, Mass. — The New England Patriots expected to have rust coming off a long layoff and with a minimal amount of practice time after dealing with several positive coronavirus tests.

They didn’t count on the myriad of mistakes they had in Sunday’s 18-12 loss to Denver that has now left them with a losing record through five games for the first time since 2001.

New England had a 13-day layoff between games after eight players went on the reserve/COVID-19 list, including quarterback Cam Newton and reigning Defensive Player of the Year Stephon Gilmore.

Both returned to the lineup Sunday, but the team was still short-handed after right guard Shaq Mason and defensive lineman Derek Rivers were added to the list on Saturday, as was running back Sony Michel, who was already on injured reserve because of a leg injury. Those moves came a day after center James Ferentz was added to the COVID-19 list, prompting the team to cancel practice Friday and close its facility.

“Some stuff you can’t control, and it is out of your hands sometimes,” Gilmore said. “At the end of the day, we are professional football players and we have to be able to go out there and compete and not make excuses and lay it out all on the line for your teammates.”

The result was sluggish play on both sides of the ball Sunday. Denver was held out of the end zone, but got field goals on each of its first six drives and led 18-3 after three quarters.

Nine of those points directly followed Patriots errors, including three turnovers.

“Didn’t do anything well enough to win today,” Coach Bill Belichick said.

Newton said he thinks the lack of practice time was a factor, but wasn’t something they couldn’t have overcome.

“We’re expected to do our job and play at a high level and we didn’t do that today,” he said. “Anytime you turn the ball over that many times, the success rate is extremely low. But yet we still that opportunity to win, and we just got to find ways to do that.”

The Patriots opened their first possession with five straight runs before Newton had an attempted screen pass to James White deflected by defensive end Shelby Harris and intercepted by defensive lineman DeShawn Williams. It was Harris’ 11th tipped pass since 2019, which leads all NFL defensive linemen.

Denver’s ensuing drive quickly stalled after three plays. But Brandon McManus kicked his second field goal to make it 6-0.

New England drove to the Denver 19 in the second quarter on its third possession of the game. But that drive was upended when Joe Thuney snapped the ball over Newton’s head for a loss of 15 yards. The Patriots had to settle for Nick Folk’s 41-yard field goal.

It was 12-3 in the third quarter when Denver was facing a third-and-6 on the New England 8. Gilmore got caught behind Tim Patrick and was called for defensive holding in the end zone. It gave the Broncos a fresh set of downs and eventually ended in McManus’ 20-yard field goal.

It was New England’s only penalty for the game.

“We made plays, but it is a team game. We could have made more plays and that’s how I look at it,” Gilmore said “It is a team game, we win as a team and lose as a team, and we lost today and that is how it went.”

Then in the third quarter, tight end Ryan Izzo had a costly fumble following a catch in Broncos’ territory, setting up a 54-yard field goal by McManus.

Newton’s touchdown run and another field goal by Folk got the Patriots within a touchdown in the closing minutes. But Newton’s rushed pass attempt on fourth down to receiver N’Keal Harry ended up well wide and clinched Denver’s victory.

“I knew I was going to get hit. So I just tried to find a spot to give him, so he could make a play on it,” Newton said.

Despite the miscues, he said there’s no time to panic going forward.

And like Gilmore, he said he’s not going to dwell on his bout with coronavirus or use it as an excuse for what went wrong Sunday.

“Obviously everybody knows what the situation was and it is what it is, and I just know for me here moving forward, I just got to play better football and that’s what I’m going to try to do,” he said.