ATLANTA — Matt Ryan shredded Carolina’s defense, passing for a team-record 503 yards and four touchdowns, Julio Jones had 12 receptions for a Falcons-record 300 yards, and Atlanta beat the struggling Panthers 48-33 on Sunday.

One week after being held to one catch in a win at New Orleans, Jones had a 75-yard scoring catch late in the game as Atlanta (3-1) solidified its early hold on the NFC South lead.

The totals by Ryan and Jones are the most ever allowed by Carolina.

Carolina quarterback Cam Newton left the game in the fourth quarter and was evaluated for concussion symptoms after taking a hit from Deion Jones on a successful 2-point run.

There appeared to be helmet-to-helmet contact but there was no penalty on the hit.

The Panthers may have to face Tampa Bay next Monday night without Newton. Due to NFL policy on players sustaining concussions, Newton was not available for postgame interviews and Rivera had no update on the injury.

The Panthers (1-3) scored three fourth-quarter touchdowns, including scoring passes from Newton’s replacement, Derek Anderson, to tight end Greg Olsen and Corey Brown.

Robert Alford’s 30-yard interception return for a touchdown with 1:14 remaining clinched the win. Alford picked off another pass from Anderson to end Carolina’s final possession.

TEXANS 27, TITANS 20: Will Fuller had a tiebreaking 67-yard punt return for a touchdown and host Houston won in its first game without J.J. Watt.

It was the first time Houston (3-1) had played without its star defensive end since the 2010 season after Watt, who is out for the season after back surgery.

RAIDERS 28, RAVENS 27: Derek Carr threw four touchdown passes, the last to Michael Crabtree with 2:12 left, as visiting Oakland (3-1) beat previously undefeated Baltimore (3-1).

After the Ravens rallied from a nine-point deficit in the fourth quarter to go ahead with 3 minutes remaining, Carr directed a 66-yard drive that ended with a 23-yard strike to Crabtree in the back of the end zone.

Carr went 25 for 35 for 199 yards.

Three of his TD passes went to Crabtree, who finished with seven catches for 88 yards to help Oakland win its third straight on the road.

SEAHAWKS 27, JETS 17: Russell Wilson was sharp and efficient despite playing with a sprained knee, throwing three touchdown passes in Seattle’s win over New York (1-3) at East Rutherford, New Jersey.

Wilson finished 23 of 32 for 309 yards while wearing a brace on his leg.

WASHINGTON 31, BROWNS 20: Kirk Cousins threw three touchdown passes, including two to tight end Jordan Reed, and Washington cashed in on several trips to the red zone to beat Cleveland at Landover, Maryland.

Washington (2-2) scored four red zone touchdowns against the Browns (0-4) after going 3 for 14 in their first three games of the season.

Cousins connected with Reed for 8- and 9-yard touchdowns, Chris Thompson for a 5-yard score, and running back Matt Jones scored from 1 yard out during his 117-yard game.

JAGUARS 30, COLTS 27: Blake Bortles threw for two touchdowns and ran for another as Jacksonville held off a furious Indianapolis rally to win in London for the Jaguars’ first win of the season.

The victory at a raucous Wembley Stadium boosted Jacksonville into a tie with Indianapolis at 1-3 in the AFC South.

BEARS 17, LIONS 14: Brian Hoyer threw for 302 yards and two touchdowns as host Chicago earned its first win of the season.

The Bears (1-3) got a win after starting 0-3 for the second time in as many seasons under Coach John Fox.

Hoyer was on target in his second straight quarterback start with Jay Cutler nursing a sprained right thumb, completing 28 of 36 passes.

BRONCOS 27, BUCCANEERS 7: Paxton Lynch made his NFL debut sooner than expected, stepping in for injured starter Trevor Siemian to help Denver stay unbeaten with a win at Tampa, Florida.

Siemian left the game with two minutes remaining in the first half with what the defending Super Bowl champions described as an injury to his left (non-throwing) shoulder.

RAMS 17, CARDINALS 13: Tavon Austin returned a punt 47 yards to set up Case Keenum’s 4-yard touchdown pass to Brian Quick with 2:41 to play, as Los Angeles improved to 3-1 for the first time in a decade with a win at Glendale, Arizona.

SAINTS 35, CHARGERS 34: Drew Brees threw two touchdown passes in the final 4 minutes, 50 seconds to rally visiting New Orleans to a stunning win against Philip Rivers and San Diego, who blew a 13-point lead by committing two crucial turnovers.

COWBOYS 24, 49ERS 17: Ezekiel Elliott ran for 138 yards and a touchdown and Dak Prescott threw for two scores to help Dallas overcome an early 14-point deficit at Santa Clara, California.