Red Sox starting pitcher Nick Pivetta, left, is relieved by Manager Alex Cora, right, after giving up a two-run home run to Giancarlo Stanton during Boston’s 4-2 loss to the Yankees on Saturday in New York. John Minchillo/Associated Press

NEW YORK — Giancarlo Stanton became the first player to homer against Boston in six straight games, hitting a tiebreaking, two-run drive in the sixth inning that gave the New York Yankees a 4-2 win over the Red Sox on Saturday.

Anthony Rizzo also homered for the second straight day to start New York’s comeback from an early deficit, hitting a tying two-run drive in the fourth.

Luis Severino made his first start for the Yankees since the 2019 AL Championship Series as New York improved to 2-0 for the first time since 2018.

Stanton broke a 2-2 tie when he drove an 0-1 slider from Nick Pivetta (0-1) into the first row of the left-field bleachers – a 437-foot drive over Boston’s bullpen.

Stanton and Rizzo became the first players in Yankees history to homer together in both of a season’s first two games. They also became the ninth set of teammates since 1900 to each hit homers in both of a season’s first two games, the Elias Sports Bureau said.

“Good to see the big boys doing some damage,” Manager Aaron Boone said.

Stanton’s streak of six straight games with home runs against the Red Sox includes a drive in last year’s AL wild-card game – a 6-2 Yankees loss.

“Just fortunate to get some balls over the plate and be on time and get the barrel to it,” Stanton said. “I can’t say it’s the rivalry or anything. I’m doing my homework and I’m getting the ball over the plate.”

Three players had homered in five games in a row against Boston: Mickey Mantle (1954), Ken Griffey Jr. (1996-97) and Jim Thome (1997).

After serving as the designated hitter Friday, Stanton played right field. Stanton hit nine of his 35 homers last year in 16 games as an outfielder.

“I can’t tell you why I hit them when I’m playing outfield or DH,” Stanton said. “It’s just a different rhythm to the game. I got to be able to master both of them because I’m going to do both.”

Alex Verdugo hit a two-run homer in a 31-pitch second inning off Severino, who returned late last season from Tommy John surgery. The 28-year-old All-Star right-hander, a 19-game winner in 2018, allowed five hits in three-plus innings, struck out five and walked none. He threw 65 pitches, including 35 four-seam fastballs that averaged 97.8 mph.

Boston and went 0 for 10 with runners in scoring position and dropped to 0-2 for the second straight season. Last year, the Red Sox opened with three straight losses at home to Baltimore, then won nine in a row and held a share of first place in the AL East for 85 days.

Pivetta allowed four runs and four hits in 5 2/3 innings.

“It’s just my mistake right there,” Pivetta said of the Stanton homer. “It just came out of my hand in a weird way and it was a hanger.

Six relievers followed Severino with a hitless inning each.

Ron Marinaccio, a 26-year-old right-hander, stranded an inherited runner in the fourth in his major league debut. Lucas Luetge (1-0) pitched the sixth, and Aroldis Chapman worked around a throwing error by new shortstop Isiah Kiner-Falefa for his first save.

WEB GEM

Rizzo homered after center fielder Kiké Hernández made a leaping catch at the center-field fence to rob Aaron Judge of an extra-base hit. Judge’s drive would have been a home run in 21 ballparks.

COMMUNICATION BREAKDOWN

Boone went to to the mound because Severino left the Pitch Com signaling device in the dugout. An inning earlier, Severino appeared to experience trouble hearing the signs in the device during the at-bat to Vázquez. He had the cup his ears to hear the signal because of the two-strike siren blaring from the sound system.

DEBUT

Marinaccio relieved Severino in the fourth. He began his career by walking Trevor Story and got two strikeouts after a pep talk from Rizzo.

“I think overall I felt pretty calm,” Marinaccio said.

A native of Toms River, New Jersey, Marinaccio said his parents, brother, fiancée and over 100 friends were in the stands.

Marinaccio became the fourth player born in Toms River to appear in the majors and the third for the Yankees. The others were Al Leiter and Andy Messersmith.

“I love his makeup, and so I knew he’d get through it,” Boone said.

TRAINER’S ROOM

Red Sox: Shortstop Xander Bogaerts went 0 for 3 with three strikeouts and a walk after exiting Friday’s game with a tight right hamstring. … Right-hander Matt Barnes (tight back) said he is feeling better. Barnes was unavailable Friday after tweaking his back during Thursday’s workout. … Left-hander Josh Taylor (strained back) will throw batting practice next week at the spring training complex in Fort Myers.