Chris Sale allowed two hits in five innings in his return from the COVID-19 list and Boston beat Baltimore, 7-1, on Friday at Fenway Park. Michael Dwyer/Associated Press

BOSTON — Chris Sale returned from COVID-19 to pitch five innings of two-hit ball, and Bobby Dalbec homered to help the Boston Red Sox beat Baltimore 7-1 on Friday night and send the Orioles to their 100th loss of the season.

One night after beating the New York Yankees in a walk-off win, Baltimore again helped the Red Sox close in on a playoff berth.

Alex Verdugo had three hits and a sliding catch in the left-field corner, and Hunter Renfroe had a three-run double for the Red Sox, who entered the night in a virtual tie with Toronto for the two AL wild-card spots; New York was a half-game back. The Yankees beat Cleveland 8-0 and Minnesota topped Toronto 7-3 on Friday, leaving Boston and New York in playoff position at the end of the night, with the Blue Jays a half-game back.

Baltimore became the first team to reach 100 losses this season; Arizona entered the night at 99. The Orioles have lost at least 100 in each of the last three 162-game seasons.

Sale (4-0) spent all of 2020 and the first 4½ months of this season recovering from Tommy John surgery. Then, after five starts, he tested positive for the coronavirus on Sept. 10 and was scratched from the following start. He was activated from the IR on Friday.

The seven-time All-Star allowed a home run off the Green Monster light tower to Austin Hays, and Cedric Mullins’ single. Sale struck out one, walked none and hit a batter, leaving after five innings and 79 pitches with a 3-1 lead.

J.D. Martinez doubled in a run in the fifth to make it 4-1. All four runs were charged to Keegan Akin (2-10), who gave up six hits and three walks before leaving when he walked the leadoff batter to start the fifth.

Renfroe hit a bases-loaded double in the sixth that Mullins dove for in center but couldn’t get, scoring three more runs.

The Red Sox wore their yellow and blue Boston Marathon-themed uniforms that they had debuted on Patriots Day.

TRAINER’S ROOM

Orioles: Trey Mancini (right oblique/abdomen) returned to the lineup at DH, and Pedro Severino (upper leg/groin discomfort) was back at catcher after missing back-to-back games.

Red Sox: Sale was reinstated from the COVID-19 injured list before the game. Right-handed reliever Matt Barnes was also reinstated from the list and returned from his injury rehab assignment with Double-A Portland. To make room for them, RHP Ryan Brasier was optioned to Triple-A Worcester and RHP Michael Feliz was designated for assignment.