Minnesota’s Josh Donaldson connects for a tiebreaking, two-run homer in the 10th inning Wednesday night against the Boston Red Sox at Fenway Park. Charles Krupa/Associated Press

BOSTON — Josh Donaldson hit a two-run homer to lead off the 10th after Boston rallied from a four-run deficit to send the game into extra innings, and Jake Cave added a three-run shot to help the Minnesota Twins beat the Red Sox 9-6 on Wednesday night.

Donaldson and Jorge Polanco homered for the second straight game, and Miguel Sanó hit a 495-foot homer that is the longest in the majors this year and one of the longest in the history of Fenway Park – just 7 feet shorter than Ted Williams’ 502-foot “red seat” shot.

Minnesota led 4-0 before Boston scored one in the seventh, one in the eighth, and then tied it on Kyle Schwarber’s two-run homer off Alex Colomé (4-4) in the ninth inning. Xander Bogaerts singled and Rafael Devers walked before the Twins closer retired the next three batters to send the game into extra innings.

That’s when Hansel Robles, who was in line to take over as closer after Matt Barnes blew big leads in back-to-back games this week, gave up Donaldson’s homer. After a hit and a hit batsman, Cave sent the first pitch he saw to the same spot over the Boston bullpen to make it 9-4.

Colomé earned the win despite blowing a 4-2 lead in the ninth. Kiké Hernández homered in the bottom of the 10th before Ralph Garza Jr. retired Schwarber on a popup to third base to end the Twins’ four-game losing streak.

Schwarber had three hits for Boston, which holds a 1 1/2-game lead over Oakland in the AL wild-card race.

LONG SHOTS

Sanó’s third-inning home run is the longest at Fenway since Statcast began measuring them in 2015. It left the ballpark high above the 379-foot marker at the center field edge of the Green Monster, clearing the 37-foot wall, four rows of counter-height seats, an aisle behind them and a 6-foot fence behind that.

Williams’ homer off Fred Hutchinson on June 9, 1946, landed 37 rows up in the right-field bleachers and hit Section 42, Seat 21 occupant Joe Boucher on the head, breaking his straw hat. It was measured at 502 feet; the location is now marked with a lone red seat.

In 2001, using a system that is less accurate than the one Statcast now uses, a Manny Ramirez homer was measured at 501 feet – somewhat suspiciously preserving the Williams legend.

Sanó’s homer left the ballpark to the left of the flagpole behind the hitter’s eye in center, depriving him of another distinction: Only a half-dozen players have ever hit balls out of Fenway and to the right of the flagpole, with the last one by Jim Rice in 1975.

FOR STARTERS

Bailey Ober struck out seven in five shutout innings, allowing four hits and a walk. Nick Pivetta gave up four runs on six hits and two walks, striking out five in four innings.

BASE RUNNING

The Red Sox cost themselves a run in the third when, with two outs, Christian Vázquez held up at second waiting to see if Schwarber’s line drive landed safely in center field. It fell in for a single, but since Vázquez wasn’t running on contact, he failed to score and was stranded on third when Bogaerts flied out to end the inning.

The next inning, after Minnesota scored two in the top half to take a 4-0 lead, Alex Verdugo hit a high fly to left that caught the top of the Green Monster. Not only did Verdugo spend too much time admiring it to take what should have been an easy double, he made the turn too wide at first and was thrown out there.

Verdugo did run hard on Hunter Renfroe’s wall double in the eighth, going from first to third and then scoring to make it 4-2 when the relay was mishandled.

TRAINER’S ROOM

Twins: Outfielder Byron Buxton had a pair of hits during a Triple-A rehab start for St. Paul as he tries to work his way back from a broken bone in his finger that was hit by a pitch.

Red Sox: Pinch-hitter Kevin Plawecki was hit in the hand by a pitch in the eighth inning. He left for a pinch runner, which may not have been injury-related.