Orioles catcher Chance Sisco prepares to tag out Boston’s Marwin Gonzalez, who was trying to score on a hit by Christian Arroyo. The Red Sox won in 10 innings, 6-4. Julio Cortez/Associated Press

BALTIMORE — Rafael Devers homered and the Boston Red Sox scored twice in the 10th inning on a wild pitch and an RBI single by Christian Vázquez to extend their winning streak to five games with a 6-4 victory over the Baltimore Orioles on Saturday night.

Baltimore outfielder Trey Mancini hit his first home run since his return from cancer surgery that caused him to miss the 2020 season. It was Mancini’s first homer since Sept. 28, 2019.

The Orioles scored twice in the eighth to take a 4-3 lead on a fielder’s choice by Maikel Franco and an RBI single by Freddy Galvis off Adam Ottavino. Boston tied it in the ninth on a fielder’s choice by Bobby Dalbec against César Valdez, who had converted his two previous save chances.

Michael Chavis, recalled from the alternate training site earlier in the day, entered as a pinch-runner in the 10th and scored on a low pitch by Dillon Tate (0-1) that rolled to the backstop. Vázquez added an insurance run with a single off Wade LeBlanc.

Matt Barnes (1-0) struck out two in the ninth and Matt Andriese earned Boston’s first save of the season.

Devers had two RBI for the Red Sox, who have won five consecutive games for the first time since August 2019.

The Orioles were 1 for 13 with runners in scoring position.

Boston took a 2-0 lead in the first. Devers hit an RBI single and then got picked off first, but stayed in a rundown long enough to allow Xander Bogaerts to score from second.

Mancini and Anthony Santander responded with back-to-back homers off Garrett Richards in the bottom half.

Devers broke the deadlock with a towering homer to right-center off rookie left-hander Bruce Zimmermann in the sixth.

Zimmermann, a Maryland native who grew up rooting for the Orioles, made his third career start, but it was his first game at Camden Yards with fans in attendance (9,307). Zimmermann allowed three runs and seven hits with four strikeouts and a walk over six innings.

• Red Sox outfielder/designated hitter J.D. Martinez has cold symptoms and was placed on the COVID-19 injured list before Saturday’s game.

Martinez underwent coronavirus testing and the team is awaiting the results.

Going on the COVID-19 IL does not require a positive test. If he tests negative twice, Martinez can return to the lineup for the series finale Sunday at Baltimore.

“We feel pretty confident that he’ll be able to be with us (Sunday), but obviously we have to wait,” Red Sox Manager Alex Cora said.

Martinez has been of the hottest hitters in MLB to start the season. He is batting .433 (13 for 30) with seven doubles, two home runs and 12 RBI.

Martinez entered the day leading all major league players in extra-base hits with nine. He has also recorded at least one extra-base hit in all of his team’s first seven games of the year, making him one of five players in MLB history to accomplish that feat.

Cora fully understands the league’s precaution with Martinez.

“I’ll tell you my story in spring training,” Cora said. “We got this app that they asked you how you feel, right? I had allergies in spring training, and you got to be honest, you know, as far as like, ‘OK, so I felt this.’ And as soon as I sent it, I got a text, a phone call and a lot of people panic and in less than five minutes. So I had to go to JetBlue Park, do the rapid test, stay in my office until they gave me the green light and that was it.

“But it’s understandable, right? We know what we are fighting against. But we don’t know how it moves or when we can get it, where, but I understand the protocols. I’m OK with it. So if we don’t have J.D. for one day, so be it, you know? Somebody has to step up and do the job tonight.”

Teams can carry up to five players on a taxi squad on the road in case of a coronavirus outbreak.

The Red Sox recalled Chavis from the alternate training site to fill the opening on the 26-man roster.