DENVER — Leonard Fournette ran for a career-high 225 yards and Josh Lambo kicked a 33-yard field goal as time expired, sending Jacksonville past winless Denver.

The Broncos (0-4) not only were victimized by a last-second field goal for the second time this season, but they blew a 14-point lead at home in a loss for the first time since 2006.

Gardner Minshew II drove the Jaguars, one of four AFC South teams who are 2-2, into field goal range after Joe Flacco’s 8-yard TD throw to Courtland Sutton with 1:38 left gave Denver a 24-23 lead.

Eerily reminiscent of their 16-14 loss to the Bears in Denver two weeks ago, the Broncos helped ignite the winning drive by getting whistled for roughing the passer.

Against Chicago, it was Bradley Chubb’s questionable penalty, which the league admitted was a bad call. Against the Jaguars, it was a flag by Von Miller, who reached up and struck Minshew in his neck just as he released his pass in a chaotic pocket.

Miller’s foul spoiled his big day in which he collected his 99th and 100th career sacks and drew several holding penalties.

Chiefs 34, Lions 30

DETROIT (AP) — Darrel Williams ran for a go-ahead, 1-yard touchdown with 23 seconds left after Patrick Mahomes’ run converted a fourth down, lifting the Kansas City Chiefs to a 34-30 win over the Detroit Lions.

Saints 12, Cowboys 10

NEW ORLEANS (AP) —Vonn Bell’s forced fumble and two recoveries helped the Saints stifle a Dallas offense that had rolled through its first three games, and Wil Lutz kicked four field goals to lift New Orleans over the Cowboys.

Bucs 55, Rams 40

LOS ANGELES (AP) — Jameis Winston passed for 385 yards and threw two of his four touchdown passes to Chris Godwin, and Ndamukong Suh returned Jared Goff’s fumble 37 yards for a touchdown with 1:06 to play in Tampa Bay’s victory over previously unbeaten Los Angeles.

Giants 24, Redskins 3

EAST RUTHERFORD, N.J. (AP) — Daniel Jones worked his magic again, Saquon Barkley’s replacement Wayne Gallman scored two touchdowns, and Jabrill Peppers scored on a 32-yard interception return.

Jones (23 of 31 for 225 yards) has sparked the Giants (2-2) since replacing two-time Super Bowl MVP Eli Manning as the starting quarterback. He rallied New York from an 18-point deficit in his first start against the Buccaneers last week and was solid early, leading New York to touchdown runs on its first two series.

Gallman, who is going to start for the foreseeable future with Barkley battling a high ankle sprain, caught a 6-yard TD pass and scored on a 1-yard run to stake New York to a 14-0 lead.

Seahawks 27, Cards 10

GLENDALE, Ariz. (AP) — Russell Wilson threw for 240 yards a touchdown, Jadeveon Clowney returned an interception for a touchdown and Seattle beat Arizona.

Bears 16, Vikings 6

CHICAGO (AP) — Chase Daniel threw for 195 yards and a touchdown after Mitchell Trubisky got knocked out of the game with a left shoulder injury on the opening possession, and Chicago swarmed NFL rushing leader Dalvin Cook in a victory over Minnesota.

Raiders 31, Colts 24

INDIANAPOLIS (AP) — Derek Carr led the Oakland Raiders to touchdowns on three of their first four possessions, and Erik Harris returned a late interception 30 yards for a score to seal the victory.

Panthers 16, Texans 10

HOUSTON (AP) — Kyle Allen threw for 232 yards and the Panthers overcame his three fumbles with help from a big defensive play.

Browns 40, Ravens 25

BALTIMORE (AP) — Baker Mayfield threw for 342 yards and a touchdown, Nick Chubb ran for a pivotal 88-yard score and the Browns earned a share of first place in the AFC North.

Chubb finished with 165 yards and three scores against the league’s third-ranked rushing defense. Jarvis Landry had eight catches for 167 yards before leaving with a suspected concussion.

Titans 24, Falcons 10

ATLANTA (AP) — Marcus Mariota threw three first-half touchdown passes, two to A.J. Brown, and the Tennessee defense had three fourth-down stops.

Chargers 30, Dolphins 10

MIAMI GARDENS, Fla. (AP) — Philip Rivers threw for 310 yards and two scores to help the Chargers win in Miami for the first time in 38 years.