MINNEAPOLIS

George Springer reached base in all six plate appearances and hit two of Houston’s season-high six home runs to lead the Astros to their seventh straight victory, 17-6 over the Minnesota Twins on Wednesday.

Carlos Correa, Alex Bregman, Evan Gattis and Marwin Gonzalez also went deep for the Astros, who scored 40 runs in the three games to set a franchise record for runs in a series of any length. They had 19 hits on Wednesday and 37 in the series.

Brian Dozier, Eddie Rosario and Jason Castro homered for the Twins, who have lost four straight. Hector Santiago (4-5) gave up six runs and eight hits and walked three in six innings, three days after he was an emergency fill-in during the 15th inning of a loss to Tampa Bay.

Springer’s two homers traveled an estimated 900 combined feet, including a moon shot off of Ryan Pressly in the six-run seventh inning that landed just short of the third deck in left-center field. That was measured at 473 feet, the second longest homer in the majors this season behind a 481-footer by Arizona’s Jake Lamb on April 29.

Padres 2, Cubs 1

SAN DIEGO (AP) — Rookie Franchy Cordero tripled in the eighth and scored on Yangervis Solarte’s fielder’s choice and San Diego handed Chicago its season-high sixth straight loss.

Luis Perdomo and two relievers combined to hold the struggling Cubs to three hits. The rebuilding Padres won their season-high fourth straight game and swept the Cubs for the first time since Aug. 6-8, 2012.

The defending World Series champion Cubs, who were swept at the Dodgers during the weekend, finished their first winless trip of at least six games since Aug. 3-8, 2012, when they also lost three at Los Angeles and three at San Diego.

Orioles 10, Yankees 4

BALTIMORE (AP) — Adam Jones homered and drove in five runs, Chris Davis added a two-run shot and Baltimore beat Masahiro Tanaka and New York.

Baltimore took two of three from the AL East leaders after coming in with a seven-game losing streak. The Yankees have lost 11 straight series in Baltimore — the second-longest road skid in franchise history behind a 12-series drought at Oakland from 1985-91.

Back in the lineup after missing four straight games with a sore hip, Jones contributed an RBI double to a four-run third inning, hit a three-run homer in the fourth and drove in a run with an infield hit in the eighth.

Cardinals 2, Dodgers 1

ST. LOUIS (AP) — Dexter Fowler hit a tiebreaking homer in the eighth inning to back Carlos Martinez and give St. Louis a victory over Los Angeles.

D-Backs 6, Pirates 5

PITTSBURGH (AP) — Chris Owings singled home the go-ahead run in the 14th inning and Arizona outlasted Pittsburgh in a game that took more than 4? hours to play — plus a 93-minute rain delay.

Blue Jays 5, Reds 4

TORONTO (AP) — Devon Travis hit a tiebreaking two-run home run in the seventh inning, Luke Maile also hit a two-run home run, and Toronto beat Cincinnati to complete a three-game sweep.

Brewers 7, Mets 1

NEW YORK (AP) — Eric Thames hit his first home run in three weeks, Keon Broxton also went deep against an ineffective Jacob deGrom, and Milwaukee beat New York for just its third win in 10 games.

A’s 3, Indians 1

CLEVELAND (AP) — Sean Manaea allowed three hits in seven innings, Chad Pinder homered twice and drove in all three Oakland runs, and the Athletics defeated Cleveland.

Marlins 10, Phillies 2

MIAMI (AP) — Justin Bour hit two home runs, increasing his season total to 15, and Miami completed its first series sweep of the season by beating Philadelphia before a sparse crowd.

Nationals 3, Giants 1

SAN FRANCISCO (AP) — Max Scherzer struck out 11 in a five-hitter and Washington beat San Francisco to complete a three-game sweep.

Rays 7, Rangers 5

ARLINGTON, Texas (AP) — Logan Morrison and Derek Norris homered in a three-run 10th inning to cap a late Tampa Bay comeback against Texas.

Tigers 6, Royals 5

KANSAS CITY, Mo. (AP) — J.D. Martinez and Justin Upton each hit a two-run double with two outs in the third inning, and Detroit held off Kansas City.

Angels 2, Braves 1

ANAHEIM, Calif. (AP) — Eric Young Jr. made his first home run of the season a timely one, hitting a solo shot in the eighth inning to lift Los Angeles over Atlanta.

Mariners 5, Rockies 0

SEATTLE (AP) — James Paxton and three relievers combined on a four-hitter as Seattle blanked Colorado.

Paxton (4-0), activated from the disabled list before the game, retired 16 of his first 17 batters.