WASHINGTON — Bryce Harper tied it with a pinch-hit home run in the ninth inning, pitcher Oliver Perez put down a bunt in the 15th that kept the game going and Chris Heisey homered in the 16th to give the Washington Nationals a wild 6-5 win over the Minnesota Twins.

At 5 hours, 56 minutes, it was the longest regular-season game in Nationals history, and one of the craziest, too.

Harper was supposed to have a day off, but stepped up to lead off the ninth with Washington trailing 4-3 and connected for the first pinch-hit homer of his career.

The Nationals were down 5-4 in the 15th when Danny Espinosa drew a two-out walk and stole second. With no one else left to hit, Perez (1-0) batted for the first time since 2010 and bunted down the third-base line. Catcher John Ryan Murphy picked up the ball but threw it wildly past first, allowing Espinosa to score.

American League

RAYS 8, YANKEES 1: Steven Souza Jr. homered twice on his 27th birthday and Tampa Bay went deep five times, finally giving Drew Smyly some run support in a victory in New York.

BLUE JAYS 6, A’S 3: Jose Bautista hit a two-run homer, Ezequiel Carrera added a solo shot and Toronto won at home.

INDIANS 6, TIGERS 3: Francisco Lindor got three hits and Cleveland overcame an early injury to starting pitcher Carlos Carrasco to win in Detroit, finishing a three-game sweep.

WHITE SOX 4, RANGERS 1: Mat Latos pitched six solid innings for his fourth consecutive win, and Chicago beat Texas in Chicago.

ROYALS 6, ORIOLES 1: Yordano Ventura settled down after a shaky first inning, Eric Hosmer homered to continue his hot streak and host Kansas City beat Baltimore.

MARINERS 9, ANGELS 4: Wade Miley overcame a shaky first inning that included a home run by slumping Albert Pujols to post his first victory in a Mariners uniform, helping Seattle win in Anaheim, California.

NATIONAL LEAGUE

Pirates 12, Diamondbacks 10: Arizona pitcher Shelby Miller played left field and chased after Sean Rodriguez’s go-ahead double in the 13th inning before striking out to end the game, and Pittsburgh beat the Diamondbacks in Phoenix.

CUBS 9, REDS 0: Anthony Rizzo drove in four runs with his 10th career two-homer game, Jason Hammel pitched six scoreless innings and Chicago routed host Cincinnati.

BREWERS 8, PHILLIES 5: Scooter Gennett and Alex Presley homered in a six-run sixth inning, backing an encouraging outing by struggling starter Wily Peralta in host Milwaukee’s victory over Philadelphia.

METS 3, BRAVES 2: Jacob deGrom made a successful return to the mound after tending to his ill infant son and an injury, pitching New York to a win in Atlanta for a three-game sweep.

MARLINS 5, GIANTS 4: J.T. Realmuto matched his career high with four hits, including a tiebreaking home run in the eighth inning, and Miami won in San Francisco to avoid a three-game sweep.

ST. LOUIS 8, SAN DIEGO 5: Jedd Gyorko homered, tripled and singled, and rookie Aledmys Diaz had a homer among his three hits as St. Louis rallied to win in San Diego.

DODGERS 12, ROCKIES 10: Chase Utley drove in the go-ahead run with a double in Los Angeles’ five-run ninth, and the Dodgers won in Denver.