BALTIMORE — Jose Bautista broke out of an early-season slump by going 3 for 3 and scoring four runs as the Toronto Blue Jays ruined the Baltimore Orioles’ home opener with a 12-5 victory Friday.

Josh Donaldson and Dioner Navarro each drove in three runs for the Blue Jays, who took control with a four-run first inning and led 10-1 in the fourth at Camden Yards.

Mark Buehrle (1-0) earned his 200th career victory, allowing one run and eight hits in six innings.

After going 0 for 12 with eight strikeouts during Toronto’s opening three-game series in New York, Bautista drove in two runs and tied his career high in runs scored.

Bud Norris (0-1) allowed eight runs and seven hits in three-plus innings.

Adam Jones homered, had a career-high tying four hits and drove in two runs for Baltimore.

TIGERS 8, INDIANS 4: Alfredo Simon took a shutout into the sixth in his debut for Detroit and Nick Castellanos hit a two-run homer as the Tigers won their fourth straight, spoiling the Indians’ home opener.

Simon (1-0) allowed three runs and seven hits in 51/3 innings.

Zach McAllister (0-1) was tagged for a career-high 13 hits.

MARLINS 10, RAYS 9: Christian Yelich drove in three runs, including a game-ending RBI single in the bottom of the 10th inning to lift host Miami to its first win.

Giancarlo Stanton also had three RBI and Michael Morse drove in two for the Marlins, who led 8-1 before the Rays scored seven runs in the seventh to tie it.

ASTROS 5, RANGERS 1: Jed Lowrie and Colby Rasmus homered for Houston, which spoiled the home debut of new Texas Manager Jeff Banister.

Rangers starter Derek Holland (0-1) left after only one inning because of tightness in left shoulder.

Collin McHugh (1-0) struck out four and allowed one run over six innings.

TWINS 6, WHITE SOX 0: Tommy Milone pitched two-hit ball into the eighth inning and Minnesota got its first win under Manager Paul Molitor, at Chicago.

Joe Mauer reached base four times, with an RBI single and three walks.

NATIONAL LEAGUE

ROCKIES 5, CUBS 1: Colorado tied its best start in franchise history, beating Chicago at home behind Troy Tulowitzki’s two-run double and Justin Morneau’s solo homer.

The Rockies, off to their first 4-0 start since 1995, got another stellar performance from their bullpen in relief of a shaky Tyler Matzek.

REDS 5, CARDINALS 4: Joey Votto hit a pair of two-run homers and Todd Frazier had a tiebreaking sacrifice fly, keeping host Cincinnati unbeaten.

The Reds are 4-0 for the first time since 2011.

PHILLIES 4, NATIONALS 1: Cesar Hernandez had a go-ahead, two-run single in a wild four-run seventh and Freddy Galvis had three hits and an RBI, leading Philadelphia to victory at home.

PIRATES 6, BREWERS 2: Pedro Alvarez homered and drove in two runs, Neil Walker had three hits and Pittsburgh avoided its first 0-4 start in nine years with a win at Milwaukee.