Actress Louise Fletcher, best known for playing on-screen villain Nurse Ratched in the 1975 movie “One Flew Over the Cuckoo’s Nest,” has died. She was 88.

Louise Fletcher holds the Academy Award she won for her leading role in “One Flew Over the Cuckoo’s Nest” in Los Angeles in 1976.  Associated Press file

The American actress died in her sleep at her home in Montdurausse, southern France, surrounded by her family, her agent David Shaul told the Associated Press on Friday, without citing a cause of death.

Fletcher won an Academy Award for best actress in her role playing a cruel nurse in a psychiatric hospital in Oregon, terrorizing her patients, among them Randle McMurphy, played by actor Jack Nicholson. Will Sampson, Danny DeVito and Christopher Lloyd also played patients in the film.

The movie directed by Milos Forman was adapted from the 1962 novel by Ken Kesey and received with great critical acclaim, sweeping up Oscar awards for best picture, best director, best actor, best actress and best screenplay in 1976.

The story follows the power tensions between McMurphy as he becomes de facto rebellious leader of the patients, challenging Nurse Ratched’s ruthless and cold authority as she doles out stiff punishment.

“I’ve loved being hated by you,” Fletcher told a star-studded crowd as she collected her Oscar award.

Other actresses such as Ellen Burstyn and Angela Lansbury had reportedly declined the role, with Fletcher telling press they likely “didn’t want to appear so horrible on the screen.”

Fletcher was in her 40s when cast in the movie and relatively unknown – having struggled to land prominent roles partly due to her height of 5 feet 10, meaning she was often taller than her acting counterparts. She had also taken time out of her career to raise her two sons with the late producer Jerry Bick, who she subsequently divorced.

“I made the choice to stop working, but I didn’t see it as a choice,” she said in a 2004 interview cited by the Associated Press. “I felt compelled to stay at home.”

Her comeback role in “Thieves Like Us” in 1974 was spotted by director Forman who cast her in the role of the icy nurse that would define her career.

Born Estelle Louise Fletcher on July 22, 1934, in Birmingham, Alabama, she was second of four children. Her parents were both deaf and in her Oscar acceptance speech she shocked crowds when she took a moment to sign out part of her speech to her parents.

“For my mother and my father, I want to say thank you for teaching me to have a dream,” she said. “You are seeing my dream come true.”

A young Fletcher left home to study drama at the University of North Carolina. “I had decided what I wanted to do with my life,” she said in a 1977 interview with Ladies’ Home Journal. “I was totally determined.”

She later moved to Los Angeles, inspired she said by actress Ginger Rogers, to follow her dream. She worked as a medical receptionist while taking acting classes. “I had a sort of blind courage in those days. Really blind,” she said.

Although she never gained the same prominence in future roles after playing Nurse Ratched, she went on to appear in “Mama Dracula,” “Exorcist II: The Heretic” and “The Boy Who Could Fly,” as well as TV shows such as “Joan of Arcadia” and “Star Trek: Deep Space Nine.”